Dietary fish oil and curcumin combine to modulate colonic cytokinetics and gene expression in dextran sodium sulphate-treated mice
نویسندگان
چکیده
منابع مشابه
Development of colonic neoplasia in p53 deficient mice with experimental colitis induced by dextran sulphate sodium.
BACKGROUND Several animal models for human ulcerative colitis (UC) associated neoplasia have been reported. However, most neoplasias developed in these models have morphological and genetic characteristics different from UC associated neoplasia. AIMS To establish a new colitis associated neoplasia model in p53 deficient mice by treatment with dextran sulphate sodium (DSS). METHODS DSS colit...
متن کاملPrevention of Chronic Experimental Colitis Induced by Dextran Sulphate Sodium (DSS) in Mice Treated with FR91
One of the main treatments currently used in humans to fight cancer is chemotherapy. A huge number of compounds with antitumor activity are present in nature, and many of their derivatives are produced by microorganisms. However, the search for new drugs still represents a main objective for cancer therapy, due to drug toxicity and resistance to multiple chemotherapeutic drugs. In animal models...
متن کاملLow dietary calcium levels modulate mucosal caspase expression and increase disease activity in mice with dextran sulfate sodium induced colitis.
Dietary calcium (Ca) positively modulates the susceptibility to colon cancer, but its effects on related or earlier colonic pathologies, such as inflammation and mucosal dysregulation, are poorly understood. We tested the effects of differing dietary Ca levels on acute dextran sulfate sodium (DSS)-induced colitis in mice. BALB/c mice received a normal Ca (NCa) diet (0.5% Ca), a high Ca (HCa) di...
متن کاملCurcumin Inhibits STAT3 Signaling in the Colon of Dextran Sulfate Sodium-treated Mice
Turmeric (Curcuma longa L., Zingiberaceae) has a long history of use in medicine for the treatment of inflammatory conditions. One of the major constituents of turmeric is curcumin (diferuloylmethane), which is responsible for its characteristic yellow color. In the present study, we have examined the chemoprotective effects of curcuminon dextran sulfate sodium (DSS)-induced mouse colitis. For ...
متن کاملCaspase-11 is expressed in the colonic mucosa and protects against dextran sodium sulphate-induced colitis
Figure S1. Caspase-11-/-mice show increased morbidity to colitis induced with 4% DSS (a) The percentage of body weight and (b) the clinical score of C57BL/6J, C11-/-and C1-/-/11-/-mice induced with 4% DSS (n = 10 per group). Data depict the mean ± SEM. Statistical significance between DSS-treated C57BL/6J and C11-/-mice is indicated.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Nutrition
سال: 2011
ISSN: 0007-1145,1475-2662
DOI: 10.1017/s0007114511000390